Welcome to the 21c Museum Hotel St. Louis, where contemporary art meets luxurious comfort! Located at 1528 Locust Street in East Saint Louis, this vibrant 4-star hotel is just 2.8mi from the hustle and bustle of the city center. Starting at just $134 per night, you can indulge in a unique experience that transforms your stay into a delightful journey through creativity and culture—all while having a fantastic time with friends or family!

Step into a world of relaxation with our fantastic amenities, including an inviting indoor swimming pool and a rejuvenating spa with wellness packages that'll leave you feeling like royalty. With a fitness center at your convenience, you'll have no excuse not to stay active during your getaway. For food lovers, our on-site restaurant offers delicious bites to fuel your adventures, while the well-stocked bar is the perfect spot to unwind after exploring the local sights. Service is at the heart of what we do—enjoy 24-hour front desk assistance, room service, and even massage options for that extra pampering.

Don't just take our word for it; with 29 enthusiastic reviews, guests rave about their experiences here, celebrating the unique combination of art, comfort, and stellar service. The soundproof rooms ensure a peaceful night’s sleep, while the terrace provides a lovely view of your surroundings. Come and discover why the 21c Museum Hotel St. Louis is not just a place to stay, but a true experience that infuses luxury with creativity!

As you explore the 21c Museum Hotel St. Louis, prepare to be wowed by the exquisite dining experience awaiting you at our on-site restaurant, Idol Wolf. This modern eatery shines with Spanish flavors, infusing every dish with creativity and flair. Whether you're celebrating a special occasion or simply winding down after a day of exploration, your culinary adventure here will be a highlight of your stay. Pair your meal with a perfectly crafted cocktail from our well-stocked bar, where friendly bartenders are eager to bring your favorite concoctions to life.

Once you've had your fill of delicious food and spirited drinks, step into our indoor swimming pool for a refreshing dip! Open year-round, this oasis invites you to float and relax while basking in the serene atmosphere. For those looking to elevate their wellness journey, our spa is ready and waiting. Book a rejuvenating massage or one of our specialized wellness packages for the ultimate in relaxation. Picture yourself unwinding after a busy day of sightseeing, cocooned in pure bliss—can you think of a better way to recharge?

When it's time to settle in for the night, the thoughtfully designed rooms at the 21c Museum Hotel St. Louis promise a restful slumber. With soundproof walls, you can kick back and unwind without the bustle of the city sneaking in. Each room is bathed in modern elegance, making it a comfortable retreat where you can reflect on the day's adventures. And if you're traveling with family or friends, you'll find spacious options like our Deluxe Suites and generous corner rooms, perfect for making memories together. Come dive into the unique fusion of art, comfort, and modern luxuries—your next unforgettable getaway awaits!